Kitzman DW, Brubaker P, Morgan T et al (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial
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As the pharmacological action and impact on CV parameters interpreted from the CV outcomes trials seemingly differed between both classes of glucose-lowering agents, they should be used accordingly, that is, after taking into consideration a patients needs and drug tolerability

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Hope DCD, Hinds CE, Lopes T, Vincent ML, Shrewsbury JV, Yu ATC, et al