Luteolin, identified in a neuronal cell-based high-throughput screen and validated in primary neurons, increased mitochondria-ER contacts, mitochondrial Ca2+ and Ca2+-dependent PDC activity without changing mitochondrial mass or structure (166)
Mangiferin directly binds to Keap1, activates the downstream Nrf2/SLC7A11/GPX4 pathway, inhibits osteoblast ferroptosis, promotes bone formation and improves osteoporosis in ovariectomized mice and iron overload mice
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Epub 2008 Jun 14