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Bedtime dosing takes advantage of the natural nocturnal GH surge and aligns with the bodys circadian hormone rhythm

Furthermore, the role of vitamin B12 in reducing homocysteine levels may also be relevant (30), as elevated homocysteine has been implicated in disruptions to hormone synthesis and metabolic homeostasis (31)

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One study conducted on rats found IGF-1 administration to increase excitatory synaptic transmission in CA1 by 40%