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Sustainable Appetite Control GLP 1 therapy reduces overeating by addressing appetite signals at a metabolic level

2010 Jul;9(3):265-8

When used carefully, berberine can fit into a well-rounded weight-loss plan alongside diet, exercise, and medical guidance when needed

For example, phentermine can affect heart rate and blood pressure, so individuals with heart disease, high blood pressure, or a history of stroke may not be safe candidates for phentermine

The nausea side effect also deters some providers, though it typically resolves with continued use

Semaglutide (STEP program) : STEP 1 (Wilding et al., NEJM 2021) enrolled 1,961 adults without diabetes