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they lose response because the compound was never working in the first place due to storage mishandling they didn't know had occurred
Vehicle-treated mice showed rapid weight loss, reflecting the catabolic state of uncontrolled diabetes
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The arylsulfonamide 40 with no structural similarities to Ang IV was one of them (Engen et al., 2016) (Figure 10)
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![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
