Proximal injection near the injury site is preferred for musculoskeletal applications because it appears to increase local tissue concentration
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Really serious reactions are super rare, but it's always good to tell your doctor about any health issues you have before you start
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Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin