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5 Dose escalation, gastrointestinal class effects, and economic constraints When the elimination half-life is short and steady-state accumulation is negligible, the most intuitive response in oral peptide and protein development has been dose escalation
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Study that establishes the efficacy and safety of liraglutide in patients with T2DM and moderate renal impairment, but shows a lack of effect of acute and prolonged therapy with this GLP-1R agonist on eGFR trajectory compared to placebo
These results reinforce the concept of metabolic syndrome-associated OA phenotype
Zhao Y, Dong W, Zhang N, Ai XH, Wang MC
The data are manually curated and of the highest quality.
