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Interaction of human telomeric DNA with N-methyl mesoporphyrin IX
(2021) shared genome sequence data for MAT1-1 and MAT1-2 idiomorphs of V
10.1016/S2214-109X(24)00276-6 Lancet Glob Health
PMID: 224 LuHZhangLDaiYRuanYCaoXCaiXet al
4.3 Creating potassium/calcium channels by ORF3a One of the important capabilities of the viral ORF3a protein is the ability to create ion channels that decrease the concentration of K i + and increase Ca i 2+ in the cell ( i + concentration leads to decreased membrane potential, which can activate voltage-dependent calcium channels (VDCCc) (283, 284), which further increases Ca i 2+ , and one of the possible effects is the activation of calcium-activated potassium channels (KCa), which further decreases K i + concentration (285)
The real gap is long-term human follow-up: none of these compounds has multi-year human safety data behind it yet
