Related to the obstacle of crossing the BBB, any drug therapeutic efficacy depends on the administered intracellular dosage that effectively reaches the desired brain area
Bisen PS, Baghel RK, Sanodiya BS, Thakur GS, Prasad GBKS
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Despite that mitochondria are exposed to the generation of oxidant species, the existence of an efficient antioxidant defense system, of which mGSH is a critical component, prevents or repairs oxidative damage generated during normal aerobic metabolism (Mari et al., 2013)
This suggests that chronic lymphocytic leukemia cells were highly active in de novo FA synthesis as well as in FA catabolism 53
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