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361 SAM enhances the levels of autophagy markers beclin-1 and LC3B-II in MCF-7 breast cancer cells and significantly increases the Bax/Bcl-2 ratio, indicating that SAM can inhibit breast cancer by inducing autophagy and apoptosis in MCF-7 cells
Seelig G, Meister A: Glutathione biosynthesis
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Effects on the liver, kidneys, and nervous system
Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk
Which Sulfur Compounds Are Important for Liver Detoxification
