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NLRP3 inflammasome activation not only facilitates inflammatory factor production but also triggers macrophage pyroptosis, epithelial-mesenchymal transition, and fibroblast activation and differentiation during pulmonary fibrogenesis [9]

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Although the pathophysiology of this hormonal imbalance may be related to several factors, including glycemic control, concomitant sleep apnea, insulin resistance, the main role is determined by the degree of central or visceral obesity and the consequent inflammatory state

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