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In January, Wegovy (a brand name for semaglutide) became available in the United States in pill form
Serious adverse events affect 32% of patients, including liver dysfunction with ALT elevation up to 311 IU/L and documented anaphylaxis cases
The STEP 1 trial showed an average weight loss of 14.9% of body weight at this dose over 68 weeks
Sports Med - Open 5(1):22
The goal is maximum consistent therapeutic effect
Still, the same substudy reported absolute lean mass reductions of several pounds in some arms, a reminder that any large caloric movement carries lean tissue with it unless training and protein intervene
