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Intermuscular use only

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We also observed diminished levels of G6pase and Pck1 (enzymes involved in gluconeogenesis) in response to CB0313.1, indicating a lower hepatic glucose output (Fig

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In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)

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