The SUSTAIN-6 Trial (Once-Weekly Semaglutide) The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) consisted of 3297 people living with T2DM, 83% with established cardiovascular disease, receiving once-weekly semaglutide (0.5 and 1.0 mg) or placebo
But others find smaller changes
Pharmacokinetic Notes: Short-acting GLP-1 RAs (exenatide BID, lixisenatide) primarily affect postprandial glucose and tend to cause more gastrointestinal side effects initially due to rapid high peaks
The most common side effects associated with Wegovy include nausea, vomiting, diarrhea, constipation, stomach pain and fatigue
Healthy Aging Growth hormone plays a central role in maintaining skin elasticity , bone density , immune resilience , and brain health
The problem of discontinuation of the drugs is big, since there are limited data and the likelihood is that the weight will be regained unless there are substantial changes in lifestyle