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GSH-responsive nanoprobes provide tumor-targeted imaging by switching on MRI, fluorescence, or photoacoustic contrast in the tumor microenvironment [97]
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To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood
Investigation of the [PMID: 2375757] Laboratory literature summary: The glutathione-binding site in glutathione S-transferases
As exemplified above, these and other studies have shown the mechanistic role of NAD + in mitochondrial function in cellular and animal models
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