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Ozempic (semaglutide) injection 0.5 mg or 1 mg was approved by the FDA in December 2017, and is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

However, approximately 510% of patients experience symptoms severe enough to require dose adjustment or discontinuation

, 92 , 1515-1542, doi: Kredich, N

1 Introduction Cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), and obesity constitute a convergent triad representing a major global health burden

Scientists now understand that beneficial bacteria help produce compounds called short-chain fatty acids (SCFAs), including butyrate, which play major roles in insulin sensitivity, satiety signaling, gut barrier integrity, and metabolic flexibility

We found that triglycerides were among the most significantly depleted lipid species across tissues from Gclc KO mice