p = 0.18), suggesting no significant difference in efficacy between Semaglutide and Liraglutide (Figure 8)
The best alternative to prescription GLP-1 for weight loss is lifestyle modification, as supplements do not effectively replicate medication
But the volume and consistency of positive outcomes suggests the medication and support structure are working for most patients
Lifestyle changes are foundational and synergistic, yet many patients will still benefit from pharmacologic support, including GLP1 therapies, for meaningful MASH improvement
Interestingly, constipation was more prevalent in the dulaglutide group (29.4%) compared with the semaglutide group (10.9%), and nausea was slightly more common with semaglutide
Lilly also has a self-pay program with discounted pricing on single-dose vials