According to Phase 2 clinical trial results published in 2023, patients taking orforglipron once a day experienced up to a 14.7% reduction in body weight
In addition to their significant A1C-lowering effects, the landmark clinical trials for these respective agents found substantial appetite suppression, less feeling of "reward" after eating, and subsequent weight loss
In a study conducted by the University of Alabama at Birmingham, mice treated with semaglutide lost over 13% of their body weight but regained 14% after stopping the treatment
The most commonly reported reactions include nausea, diarrhea, constipation, vomiting, abdominal pain, reflux, fatigue, hair loss, and injection-site irritation
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Antihistamines, decongestants like pseudoephedrine, and caffeine-based OTC products can suppress appetite short term, but using them off-label for weight loss is a bad idea