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A population-based cohort study using administrative health data from British Columbia looked at NIDDM patients who also had an IMID (i.e., rheumatoid arthritis, psoriatic disease, ankylosing spondylitis, inflammatory bowel disease, or a systemic autoimmune rheumatic disease) and newly initiated a GLP-1-RA or dipeptidyl peptidase-4 inhibitors (DPP-4is) between 2010 and 2021
Needle Anxiety People nervous about injections often feel more discomfort because tense muscles increase sensitivity
Published in NEJM 2023
Other side effects that may emerge during the first week include headache, fatigue, dizziness, and injection site reactions such as redness, itching, or mild swelling
Tirzepatide showed up to 20% weight loss in obese individuals and significant HbA 1c reduction in type 2 diabetes patients
Melanotan 2 also activates MC1R but works as a non-selective melanocortin agonist
