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In the second step, we assessed the causal effect of the mediators on ED risk using genetic instruments for the T2D and obesity ( Supplementary Tables 6 , 7 )

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A more detailed protocol can be found in the literature 15

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Clinical studies show that 0.5 mg of Ozempic reduces HbA1c levels by 1.21.4% , while the 1 mg dose lowers HbA1c by 1.51.8% , which are meaningful improvements

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