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107,108 In ME2-unexpressed gastric cancer cells, its isoenzyme ME1 is upregulated to replenish intracellular NADPH and promotes cell survival under glucose starvation and anoikis

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Klein The closest analogy comes from weight loss research

This metabolic reprogram can initially deplete energy reserves, especially if calorie intake drops too quickly or nutritional intake becomes unbalanced

Participants in the intervention and placebo groups followed an identical 16-week dose escalation protocol, titrating up to a dose of 2.4 mg weekly or maximal tolerated dose