For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)
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This persistent state, referred to as anabolic-steroidinduced hypogonadism (ASIH), has been attributed to prolonged suppression of hypothalamic GnRH signalling, desensitisation of pituitary gonadotropes, and potential structural or functional impairment of Leydig cells (79)
doi: 10.3390/biomedicines10030539 197 LouZ.-Y.ChengJ.WangX.-R.ZhaoY.-F.GanJ.ZhouG.-Y.et al