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Fat mass decreased by 17.0 kg with the combination, compared to 3.4 kg with the placebo, whereas lean mass decreased by 8.4 kg, compared to 2.6 kg

High-fat meals are known to slow gastric emptying, which can worsen symptoms such as nausea and acid reflux

Int J Obes 30:17291736 Cohen MA, Ellis SM, Le Roux CW et al (2003) Oxyntomodulin suppresses appetite and reduces food intake in humans

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N Engl J Med 2024;390:1394-407

Studies examining receptor binding have shown that GLP-RTdemonstrates strong activity at the human GIP receptor while maintaining measurable activity at both GLP-1 and glucagon receptors, creating a balanced activation profile that allows researchers to explore receptor crosstalk and multi-pathway metabolic signaling [2]