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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

S2CID 252881350

Acute alcohol consumption disrupts redox balance and causes cellular oxidative stress, which is indicated by markers such as MDA and CYP2E1

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