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4b) suggests that the metabolic response is mounted quickly but sustained and enhanced over time, given that ~75% of the metabolic DEGs at 24 h are also found at 48 h (Extended Data Fig
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(79(7)):607-610 doi:10.1038/s41430-025-01583-4
Interest in Cagrilintide has also grown because research on combination approaches suggests that targeting multiple metabolic pathways may provide stronger weight management outcomes than using a single mechanism alone
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