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Research certainly backs up creatines safety profile, with studies in certain populations showing that doses up to 30g/day for up to six months are well-tolerated.20 The most common complaints about creatine, typically present during loading phases or long-term high-dose administration, are GI disturbances and muscle cramps.9 The former can be at least partially attributed to creatines rapid degradation to creatinine when mixed into water
In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]
Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, et al