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Sustainability Concerns : The requirement for potentially lifelong therapy, combined with rapid weight regain upon discontinuation, raises questions about long-term sustainability and practical implementation

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However, this short window does not limit therapeutic benefit because BPC-157 triggers lasting biological changes rather than needing to remain constantly present

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Similarly, overexpression of hACOX1 N237S in cultured rat Schwann cells induced apoptosis, and cell death was suppressed by NACA