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Gut and mind

2018 May;115:336-343

Then theres another component of it, and thats where people end up being what we call emotional eaters

Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)

The Teichman 2006 trials showed IGF-1 increases of roughly 1.5 to 3-fold with DAC but did not measure fat mass or lean mass directly

Nausea during this period is usually manageable with lifestyle adjustments like eating smaller, blander meals and staying hydrated