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For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk
Tirzepatide currently delivers the highest average weight loss at up to 22.5 percent of body weight, while semaglutide averages 14.9 percent
The primary outcome was noninferiority of HbA1c change at 40 weeks with orforglipron compared with dapagliflozin
They can take on a myriad of morphologies and some resemble seborrhoeic keratoses with a very warty appearance
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