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A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)
In addition, because the tissues in which the GLP-1 receptor is expressed are not limited to the gastrointestinal and pancreatic glands, GLP-1RA can reduce cardiovascular risk in addition to lowering glucose and reducing body weight
Other ingredients: Rice flour (Oryza sativa), plant-based magnesium stearate, vegetable cellulose (capsule)
Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A
Orforglipron is the first oral, non-peptide, small-molecule GLP-1 RA to be approved
Diabetes pharmacotherapy has changed more in the last decade than in the four decades before it
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