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Kaneko, K

Methods: A murine SAE model was established via cecal ligation and puncture (CLP)

Epithalon recovers night release of endogenous melatonin and leads to the normalization of the hormone circadian rhythm in the blood plasma

Its primary molecular target in preclinical research is Hepatocyte Growth Factor (HGF) and its receptor c-Met, where it acts as a potent agonist to stimulate spinogenesis and synaptogenesis

An additional consequence of having GSH as redox buffer is the fact that from the pH dependence of its redox potential, it becomes possible to explain that the mitochondrial membrane potential has been observed to be independent of the matrix pH

Thyroid H 2 O 2 production is stimulated by myoinositol, which indirectly controls the inositol-dependent signaling pathway of TSH (56, 57)