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These effects appear to be mediated by central actions in the brain, not just peripheral effects on the gut

10.1016/s1570-0232(02)00618-9 J Chromatogr B Analyt Technol Biomed Life Sci

Biomedicines 13 (5), 1065

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Microdosing tirzepatide has become a popular alternative approach, particularly for people who are sensitive to gastrointestinal side effects or who want to extend their medication supply

Lipidated peptides incorporate fatty acid chains that can improve membrane permeability and extend circulation time, addressing some traditional limitations of peptide drugs