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A photothermal agent must have specific characteristics, including the lowest toxicity level and the highest biocompatibility

Elevated scrotal temperatures disrupt spermatogenesis by inducing oxidative stress, impairing mitochondrial activity, and diminishing the production of proteins essential for sperm movement (125)

Cancer Discov 14(11):20892108

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Sigalos and Pastuszak 2018, a review of the growth hormone secretagogue class covering GHRH analogs and GH-releasing peptides, concluded that these compounds are generally well tolerated but flagged decreased insulin sensitivity and elevated blood glucose as a consistent signal across the class, alongside a call for more long-term data on cancer incidence with sustained use