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Half-life is short (~10-20 minutes)
Whilst both sites are equally approved and effective, individual factors such as comfort, convenience, body composition, and personal preference may influence which site works best for each person
Separating these readouts in future trials will be essential to determine whether GLP agonism produces true reparative effects versus indirect metabolic benefits
Age approvals: Wegovy is FDA-approved for weight management in adults and some children ages 12 and older, whereas Zepbound is currently approved only for adults
Peppermint oil capsules have also shown benefit for GI discomfort in small studies
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