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Clinical trials show that Wegovy (2.4 mg dose) leads to significant weight loss when combined with a healthy diet and exercise: 85% of people lost at least 5% of their body weight 66% lost at least 10% 50% lost 15% or more On average, Wegovy users lost 14.9% of their body weight over 68 weeks compared to 2.4% in the placebo group

It had a big, big effect. Among those effects was an improvement in the patients voice

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After adjustment for baseline differences between groups, semaglutide was associated with greater weight reduction and more pronounced LDL cholesterol lowering, whereas improvements in HbA1c were broadly comparable between treatments

Meier JJ, Granhall C, Hoevelmann U, Navarria A, Plum-Moerschel L, Ramesh C, et al

This pharmacological tolerance is one reason people start considering alternatives