Research has documented MT-1s anti-inflammatory effects across skin cell models and systemic inflammatory models , characterising NF-B suppression, reduced TNF-alpha and IL-6 production, neutrophil activation inhibition, and anti-inflammatory effects in ischaemia-reperfusion and colitis models through MC1R-cAMP-mediated mechanisms
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19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced
So, the administration of compounds such as vitamins C and E, polyphenols and thiolic antioxidants (taurine, thioproline and N-acetylcisteine, among others), which are precursors of reduced glutathione (GSH), alone or in nutritional formulations containing several compounds, may be recommended, because of their antioxidant and antiinflammmatory action, for use in both laboratory animals and human subjects
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Furuse, M
