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While hemorrhoids may not be cured with topical treatment, symptomatic relief from pain and itching can be obtained with over-the-counter creams such as Preparation H and Lidocaine, or prescriptions medications like Nifedipine cream

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Imidazo[1,2-a]pyrazine derivatives (Compound 40 ) display moderate lipophilicity, high microsomal stability, favorable brain penetration, and strong in vivo exposure, although bulky R-group substitutions can impair permeability (Bartolom-Nebreda et al., 2014)