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Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

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While GLP-1 receptors are present in the kidneys and may have mild natriuretic effects, they do not typically cause clinically significant polyuria (excessive urination) in the way that diuretic medications do

However, around the time that bariatric surgerys positive effects on diabetes and cardiovascular outcomes were emerging from observational studies, researchers were taking note of the weight-loss and cardiovascular effects of the GLP-1 receptor agonist medications (GLP-1 RAs) used to treat type 2 diabetes

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