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The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro ( in vivo (S5), although DNA ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study ( Figure 7 , AQ-QI and DEAQ-QI exposure resulted in activation of the ER stress response

Scientists have explored different theories, but the most compelling include: 1

Meth Enzymol 113:484490 Celletti S, Paolacci AR, Mimmo T, Pii Y, Cesco S, Ciaffi M, Astolfi S (2016) The effect of excess sulfate supply on iron accumulation in three graminaceous plants at the early vegetative phase

1 2 PDB: 1Q0M

Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands