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Key Takeaways Different mechanisms, not rivals

184,185,199 Rational combinations, such as PARPis plus ATR or WEE1 inhibitors, aim to exacerbate replication stress and collapse replication fork stability, particularly in tumors with partial or context-specific DDR competence

Moving from 0.5% to 1%, or from 1% to 2%, represents appropriate steps

After being approved, daily lixisenatide, which is structurally like exenatide and is administered by subcutaneous injectionwas discovered to lower HbA1c by 0.8 to 0.9% [89]

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