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Czaja, M.J
Your healthcare team will determine the safest discontinuation plan based on how far along you are and your current dose
Occasional systemic symptoms including headache, nausea, dizziness or gastrointestinal discomfort in some patients
Initial assessment should focus on identifying and addressing reversible contributing factors before considering medication discontinuation
As the field of drug development continues to evolve, the importance of toxicology studies and understanding FDA guidelines is increasingly apparent
We do see relatively high proportion of GI TEAE, prominently 65% nausea and 60% vomiting at the highest dose (1.2mg), and we see a dose dependent profile on AEs (pg 159 of S-1)
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