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Although uncontrolled hypothyroidism is associated with increased stroke risk via mechanisms, such as increased vascular resistance, endothelial dysfunction, dyslipidemia, and a pro-thrombotic state [68], the increased stroke risk may be attenuated by the potential cerebrovascular protective effects of GLP-1RA [69]

doi: 10.1038/mp.2016.168

This usually balances out within a week or two as your body adjusts

Semaglutide lowered several cerebrospinal fluid Alzheimers markers by up to about 10% and produced the expected weight loss, but none of this translated into clinical benefit

It is an endogenous peptide-copper complex identified in biological systems