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GLP-1RAs increase mitochondrial content in the soleus muscle of SDT fatty rats by upregulating citrate synthase activity and cytochrome c oxidase subunit 5B protein expression (170)

First, it increases collagen, elastin, and glycosaminoglycan synthesis

The glucagon receptor component is thought largely on the basis of preclinical data to increase energy expenditure and promote fat breakdown (lipolysis), which may contribute to the substantial weight loss observed in early trials

These findings support a neuroprotective effect of GLP-1 agonists, likely mediated by mitochondrial preservation [45]

Let the water trickle down and pool at the bottom