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Gastrointestinal (GI) side effects of retatrutide are similar to those of semaglutide and other GLP-1 medications
Urolithin A, a gut-derived metabolite of ellagic acid that activates mitophagy (the selective removal of damaged mitochondria), pairs logically with MOTS-c because the two address different aspects of mitochondrial health
Most of the tests conducted on this compound are preclinical, with only a few human studies published, which have found it to effectively reduce signs of ageing and improve skin health in humans
Health, Nov
10.1016/j.cmet.2020.09.013 144
However, there were no significant differences in the proportion of patients with PDC 80% at day 360 for semaglutide QW (44.7%) compared with dulaglutide (43.3%, p = 0.86) (Table 2)
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