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Constella (linaclotide) CHMP assessment report

Pancreas 51 , 13981403 (2022)

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Additionally, macrophages can directly impede preadipocyte differentiation and stimulate the expression of pro-fibrotic factors such as -smooth muscle actin (-SMA), prompting a myofibroblast-like phenotype, an effect that is potentiated by excess glucocorticoid exposure (193)

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Research applications include wound healing, collagen synthesis, antioxidant gene activation, and fibroblast stimulation