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GIP receptor agonism appears to amplify weight loss beyond what GLP-1 alone achieves, which is part of why dual agonists like tirzepatide outperform semaglutide in head-to-head comparisons
Nausea is a common early response to GLP-1 activation regardless of dose, particularly during the titration phase when your dose is increasing each week
In addition, tumors were photographed at day 0, 3, 6, 12, and 24 after the start of the trial
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In the phase 3 trials, between 8 and 15% of participants didn't lose even 5% of their body weight, while others lost 30% or more
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