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For context, retatrutide vs semaglutide data shows retatrutide producing roughly 50% more weight loss than the highest approved semaglutide dose

Volante et al., 2003

The cohorts appeared balanced for age (median, 53 years vs

The angle matters: a 90-degree angle works for most, but for people with less subcutaneous tissue, a 45-degree angle is better

Semaglutide produces meaningful liver fat reductions of approximately 40-55%, but nowhere near the magnitude seen with retatrutide

These may include: Injection site reactions: Prolonged use of injections can cause persistent redness, swelling, or pain at the injection site