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doi: 10.3389/fphys.2014.00372

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CS, MITOL C65/67S mutant lacking ubiquitin ligase activity

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Cancer Res (2001) 61(16):62138

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When SAM is reduced from MTHFR-impaired methionine regeneration, EZH2 and other histone methyltransferases lose substrate availability producing progressive loss of repressive histone methylation marks at senescence-promoting gene promoters

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