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Reviewer 1 While the authors quantified cell proliferation of (or rather density of proliferating) RGL-NSCs and IPCs 3 weeks after TAM using EdU to label proliferating cells, this is an (understandably) narrow outcome measure in that it only assesses EdU labeled cells
UK menopause guidance notes that unscheduled bleeding on hormone therapy is common and clinical pathways exist to evaluate it
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This trial also studied a cohort receiving either 2.4 mg of liraglutide or 3.0 mg of liraglutide, with reported weight reductions of 6.3 kg and 7.2 kg, respectively, when compared to baseline
Pairing these with consistent water intake makes them significantly more effective for relieving constipation
