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In the case of liraglutide, the SCALE trial was used as the reference for percentage total body weight lost, in preference to the LEADER cardiovascular outcome trial
Larsson J, Karlsson S
GLP-1 medications also carry some serious (but rare) warnings: Potential risk of thyroid C-cell tumors (observed in rodent studies, unclear relevance in humans) Risk of gallbladder problems Pancreatitis (rare but documented) Hair loss (temporary, related to rapid weight loss rather than the drug itself) One notable advantage of GLP-1 medications: they do not cause cognitive dysfunction, do not carry teratogenicity warnings as severe as topiramate, and are not controlled substances
Comparative performance of two quantitative safety signalling methods: implications for use in a pharmacovigilance department
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